The global pandemic of COVID-19 has created historic and devastating impact. The pathophysiology and adverse clinical effects, are attributed to the uncontrolled inflammatory cascades and immune responses attributed to a “cytokine storm”. Melatonin has shown its role in anti-inflammation, antioxidant, and immunomodulation and proposes potential therapeutic tool against COVID-19. The clinical data and safety profile of melatonin in COVID-19 are currently under prospective evaluation, however, its efficacy in diseases with chronic inflammation and other viral infections propose potential current benefits of melatonin for COVID-19 infection and sequelae

Keywords: COVID-19, SARS-CoV-2, melatonin, N-acetyl-5-methoxy-tryptamine, anti-inflammatory, antioxidant, immunomodulatory


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