Innovative Journal Journal of Medical Research and Health Sciences 2589-9031 4 3 2021 3 12 Melatonin as a potential adjunctive therapy for COVID-19 1 Byung Soo Yoo, MD Steve D’Souza, MD Kevin Houston, MS Ankit Patel, MS Parth J Parekh, MD, FACP David Johnson, MD MACG, FASGE, MACP Professor of Medicine/Chief of Gastroenterology Eastern Virginia Medical School, Norfolk, VA Journal Article https://doi.org/10.15520/jmrhs.v4i3.319 Abstract The global pandemic of COVID-19 has created historic and devastating impact. The pathophysiology and adverse clinical effects, are attributed to the uncontrolled inflammatory cascades and immune responses attributed to a “cytokine storm”. Melatonin has shown its role in anti-inflammation, antioxidant, and immunomodulation and proposes potential therapeutic tool against COVID-19. 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