Innovative Journal Journal of Medical Research and Health Sciences 2589-9031 4 3 2021 3 31 Neonatal Naso-Oro-Hypopharyngeal Langerhans Cell Histocytosis: Case Report 1 Zaheer Ullah Paediatric Haemato-Oncology Consultant, Children’s Specialised Hospital, King Fahad Medical City, Riyadh, SA Ahmed AlEidan Paediatric Residents, Children’s Specialised Hospital, King Fahad Medical City, Riyadh, SA Ahmed AlHajji Paediatric Haemato-Oncology Fellow, Children’s Specialised Hospital, King Fahad Medical City, Riyadh, SA Mohammad AlShamrani Paediatric Resident, Sulaiman AlHabib Medical Group (HMG), AlRayan Hospital, Riyadh, SA Mazen AlGhofaily Paediatric Residents, Children’s Specialised Hospital, King Fahad Medical City, Riyadh, SA Abdulrahman AlWallan Paediatric Residents, Children’s Specialised Hospital, King Fahad Medical City, Riyadh, SA Mai AlQasimi Paediatric Residents, Children’s Specialised Hospital, King Fahad Medical City, Riyadh, SA Journal Article https://doi.org/10.15520/jmrhs.v4i3.330 Abstract Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder most commonly characterized by single or multiple osteolytic bone lesions demonstrating infiltration with histiocytes having bean-shaped nuclei on biopsy. These histiocytes, along with lymphocytes, macrophages, and eosinophils may infiltrate nearly every organ (most notably the skin, lymph nodes, lungs, thymus, liver, spleen, bone marrow, or central nervous system with the exception of the heart and kidneys). 1 We, hereby, describe a rare case of Naos-Oro-Hypopharyngeal LCH in a neonate. , UpToDate: Langerhans Cell Histocytosis (Treatment of Langerhans cell histiocytosis - UpToDate). Martins, Marco Antonio T., Gheno, José Luis N., Filho, Manoel Sant’Ana, Pinto, Décio S., Tenis, Carlos Alberto, Martins, Manoela D., Rare case of unifocal Langerhans cell histiocytosis in four-month-old child, International Journal of Pediatric Otorhinolaryngology, 2011, 75, 7, 963, 967, 0165-5876, 10.1016/j.ijporl.2011.04.009, Elsevier BV, https://dx.doi.org/10.1016/j.ijporl.2011.04.009 A B Azreen, Langerhans Cell Histiocytosis of Maxillary sinus, Med J Malaysia, 2012, 67, Langerhans Cell Histiocytosis of Maxillary sinus - PubMed P R Issing, E, Kaiserling, Lenar, Langerhans cell histiocytosis of the tonsil, Aryngorhinootologie, 1993, 72, 7, 346, 355