Journal of Medical Research and Health Sciences <p><strong>Journal of Medical Research and Health Sciences</strong>&nbsp; aims to improve health status and quality of care for individuals, families and communities. The Health Science Journal (Print ISSN : 2589-9023, Online ISSN: 2589-9031) aspires to provide the scientific knowledge through the publication of peer-reviewed, high quality, scientific papers and other material on all topics related to Biochemistry, Biotechnology, Health engineering, Epidemiology, Genetics, Nursing, Pharmacology, Pharmacy, Public health, Psychology, Physical therapy, and Medicine ensuring a rapid turn-around time possible for reviewing and publishing of articles freely for research, teaching and reference purposes.</p> Manuscript Central en-US Journal of Medical Research and Health Sciences 2589-9031 Impact of Obesity on Hemostatic Functions in obese women in Taif City <p><strong>Background: </strong>An epidemic increase in obesity prevalence has been observed in most of the countries. This phenomenon is an emerging health problem that is associated with increasing prevalence of obesity-related co-morbidities and mortality.</p> <p><strong>Objective</strong> :This study is designed to assess some hemostatic indices as plasma levels of fibrinogen, prothrombin time (PT), activated partial thromboplastin time (APTT), platelet count and mean platelet volume (MVP), and its association with traditional cardiovascular risk factors, plasma lipids profiles, in relation to body mass index (BMI) status in obese Saudi &nbsp;women in Taif City.</p> <p><strong>Materials</strong><strong> a</strong><strong>n</strong><strong>d</strong> <strong>M</strong><strong>e</strong><strong>th</strong><strong>o</strong><strong>d</strong><strong>s</strong><strong>:</strong> A total of 60 Saudi adult female volunteers, aged between 25-50 years, attending Al-Hada Hospital, were recruited for the study. Thirteen of them are non obese females (control group) with BMI ranged between 18 and 24.9 kg/m<sup>2</sup> and 30 are obese females (obese group) with BMI &gt;30 kg/m<sup>2</sup>.</p> <p><strong>Results:</strong> In obese group, the plasma fibrinogen levels were significantly higher (P&lt; 0.05), whereas PT and APTT were significantly shortened (P&lt; 0.05 for each) than control group. Significantly higher levels of triglycerides, low density lipoprotein (LDL) and very low density lipoprotein (VLDL), while significantly lower levels of high density lipoprotein (HDL) with P value &lt; 0.05 were found in obese group as compared to control. Significant positive correlations were found between BMI and each of plasma fibrinogen (r = 0.65, P&lt; 0.001), triglycerides (r = 0.72, P&lt; 0.001) and&nbsp; LDL (r = 0.68, P&lt; 0.001). While negative correlations were found between BMI and each of&nbsp; PT (r = - 0.58, P&lt; 0.01) and &nbsp;HDL (r =&nbsp; - 0.55, P&lt; 0.05). &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p> <p>&nbsp;<strong>Conclusion: </strong>Obesity is associated with disturbed hemostatic functions &nbsp;in obese women in Taif City which predispose to the development of thrombosis and thromboembolic complications. This highlights the need for the use of efficient preventative measures against complications of obesity.</p> Khadiga Ahmed Ismail Mariam Aish al-thobaiti Sahar Hadi Al-Salami , Asmaa Farghaly Hassan Amal Fathy Gharib Howaida Mahmoud Hagag ##submission.copyrightStatement## 2019-03-08 2019-03-08 2 3 552 560 10.15520/jmrhs.v2i3.32 HYPOGLYCEMIC POTENTIAL AND SAFETY OF AQUEOUS EXTRACT OF Aspilia mossambicensis IN ALLOXINISED DIABETIC MICE <p><strong>ABSTRACT</strong></p> <p><em>Aspilia mossambicensis </em>(Oliv.) Wild is ethnomedically used in management of numerous maladies, including diabetes mellitus. In spite of this, its efficacy and safety has not been scientifically validated. The aim of this study was to determine <em>in vivo</em> hypoglycemic activity and safety of the aqueous whole stem and leaf extracts of <em>Aspilia mossambicensis </em>(Oliv.) Wild in alloxanised diabetic swiss albino mice. The extract was assayed for hypoglycemic activity through oral administration at four doses of 50, 100, 200 and 300mg/kg body weight. The safety of the extract was evaluated by oral administration of the extract at doses of 450, 670 and 1000mg/kg body weight for twenty eight days and subsequently determining the body weights, normalized percent organ to body weight, hematological and biochemistry parameters. Phytochemicals composition was assayed through standard procedures. The extract showed strong dose independent hypoglycemic activity from the first to the sixth hour, after which diminishing activity was noted through to the 24<sup>th</sup> hour. Following oral administration of the extract in normal mice for 28 days, to assay for the safety of the extract, significantly lower rate of weekly weight gain was observed. Moreover, a significant increase in normalized percent organ to body weight of the liver and kidney was noted. A profile of hematological parameters revealed significant elevation in the level of packed cell volume and mean cell volume, lymphocytes and neutrophils count relevant to the normal control. Significant elevation in the level of AST, ALP, GGT and LDH were also noted, at higher doses of the extract. Hypoglycemic activity and the mild toxicity demonstrated by this plant at elevated doses may be due to the phytochemical composition of the plant extract. The study recommended continued use of the extract at the tested therapeutic doses.</p> Isaac Kinyua Njangiru Njeru Zephaniah Gitonga Eliud Mwaniki Njagi ##submission.copyrightStatement## 2019-03-08 2019-03-08 2 3 561 570 10.15520/jmrhs.v2i3.38 Effect of Social Skill Training on Verbal Communication Ability in Schizophrenic Patients in Madani Regional Public Hospital of Palu <p>Patients with schizophrenia tend to withdraw on a social basis. In conditions or situations that trigger the emergence of symptoms of schizophrenia also affects verbal communication. The provision of social skills training is one of the interventions with behavior modification techniques that are based on the principles of role playing, practice and feedback to improve a patient's ability to solve communication problems. This SST therapy has never been done at Madani Hospital in Palu, the usual therapy is activity group therapy (AGT). The purpose of this study is to know the effectiveness of Social Skill Training on verbal communication skills in schizophrenic patients.</p> <p>This type of research is an experimental study with a randomized pretest posttest control group design. The sample was 14 people divided into 2 groups, each group consisting of 7 people. The first group was treated with SST and the second group was done AGT. The test used to see the effect of SST and AGT on verbal communication skills by using the Paired T Test and N Gain test to determine the magnitude of the change category. To see the effectiveness of SST using the Independent T test.</p> <p>The results of the Paired T test on the effect of SST on verbal communication skills obtained a mean difference of -21.8, the value of p = 0.00 (p &lt;0.05), the value of N Gain was 0.31 (medium category). The effect of AGT on verbal communication skills was a mean difference of -13.7, p = 0.00 (p &lt;0.05), value of N Gain 0.2 (light category). The Independent T Test results mean SST = 52.4, the mean AGT = 44.7. Value p = 0.001 (p &lt;0.05).</p> <p>The conclusion of this study is that SST and AGT have an effect on verbal communication skills, SST is included in the medium category, AGT is included in the mild category. SST is more effective in improving verbal communication skills than AGT. It is recommended that nurses from the Madani Hospital in Palu be able to apply SST to schizophrenic patients as one of the mental health treatments for schizophrenic patients to improve verbal communication independently.</p> I Putu Suiraoka Nurlailah A Metrys A ##submission.copyrightStatement## 2019-03-18 2019-03-18 2 3 571 575 10.15520/jmrhs.v2i3.40