Innovative Journal Journal of Medical Research and Health Sciences 2589-9031 4 6 2021 6 21 Shrinkage of Spleen in Sickle Cell Thalassemia: A rare case report 1 Fabia Hannan Mone School of Public Health, Independent University, Bangladesh; Medical Officer, Department of Pediatrics, Anwer Khan Modern Medical College Hospital,Dhaka. K Roy Assistant Professor, Department of Pediatrics, Anwer Khan Modern Medical College Hospital, Dhaka S Halder Assistant Professor, Department of Pediatrics, Anwer Khan Modern Medical College Hospital, Dhaka M Sheefa Surveillance & Immunization Medical Officer, Dhaka North City Corporation, Bangladesh Journal Article https://doi.org/10.15520/jmrhs.v4i6.356 Abstract The most prevalent monogenic gene disorder caused by defective hemoglobin in the blood is thalassemia. Splenectomy (Total/partial) is considered to be the alternative treatment method based on hypersplenism or iron overload and is an inherited-autosomal-recessive disorder. In South Asia, the far east, the Middle East, and Eastern Mediterranean nations, it is more prevalent. Over 40,000 children are born with Thalassemia every year1. Cappellini, Maria Domenica, Porter, John B., Viprakasit, Vip, Taher, Ali T., A paradigm shift on beta-thalassaemia treatment: How will we manage this old disease with new therapies?, Blood Reviews, 2018, 32, 4, 300, 311, 0268-960X, 10.1016/j.blre.2018.02.001, Elsevier BV, https://dx.doi.org/10.1016/j.blre.2018.02.001 W A Khan, Prevalance of Beta thalassemia trait and Hb E trait in Bangladesh school children and health burden of thalassemia in our population, DS (Child) H J, 20025, 21, 1, 1, 7 Bhuiyan, RobiulH, Aklima, Jannatul, Emran, TalhaB, Dash, Raju, Palit, Sarmi, A study of the prevalence of thalassemia and its correlation with liver function test in different age and sex group in the Chittagong district of Bangladesh, Journal of Basic and Clinical Pharmacy, 2012, 3, 4, 352, 352, 0976-0105, 10.4103/0976-0105.105339, Medknow, https://dx.doi.org/10.4103/0976-0105.105339 Correia, Joao Guardado, Partial Splenectopmy in the treatment of an adult with ß-Thalassemia intermedia: A case report, International Journal of Surgery Case Reports, 2017, 41, 446, 449 Farashi, Samaneh, Harteveld, Cornelis L., Molecular basis of α-thalassemia, Blood Cells, Molecules, and Diseases, 2018, 70, 43, 53, 1079-9796, Elsevier BV, 10.1016/j.bcmd.2017.09.004, https://dx.doi.org/10.1016/j.bcmd.2017.09.004 PREMAWARDHENA, ANUJA, SILVER, SHANTHIMALA, ARAMBEPOLA, MAHINDA, OLIVIERI, NANCY F., VICHINSKY, ELLIOTT P., MERSON, LAURA, MURACO, GIULIA, ALLEN, ANGELA, FISHER, CHRISTOPHER, PETO, TIMOTHY, WEATHERALL, DAVID J., Hemoglobin E-β-Thalassemia: Progress Report from the International Study Group, Annals of the New York Academy of Sciences, 2005, 1054, 33, 39, 0077-8923, 1749-6632, Wiley, 10.1196/annals.1345.005, https://dx.doi.org/10.1196/annals.1345.005 Sultana, Gnn, The Complete Spectrum of Beta (ß) Thalassemia Mutations in Bangladeshi Population, Austin Biomarkers and Diagnosis, 2016, 3, 1, 1024, 1024 , Radiofrequency Ablation of the Spleen in Patients with Thalassemia Intermedia: A Pilot Study , , Md. Bayezid Hosen et al. Evaluation of Renal Function in Beta-Thalassemia Patients in Bangladesh. Biomiror :11-14/bm-0401133014. Wilson-Okoh, DA, Nwauche, CA, Ejele, OA, Splenic changes in sickle cell anaemia, Nigerian Journal of Medicine, 2006, 15, 1, 20, 22, 1115-2613, 10.4314/njm.v15i1.37110, Medknow, https://dx.doi.org/10.4314/njm.v15i1.37110