eng Journal of Medical Research and Health Sciences 2589-9031 4 https://doi.org/10.15520/jmrhs.v4i6.356 article The most prevalent monogenic gene disorder caused by defective hemoglobin in the blood is thalassemia. Splenectomy (Total/partial) is considered to be the alternative treatment method based on hypersplenism or iron overload and is an inherited-autosomal-recessive disorder. In South Asia, the far east, the Middle East, and Eastern Mediterranean nations, it is more prevalent. Over 40,000 children are born with Thalassemia every year1. .pdf