Metosartan induces endometrial carcinoma in rat testicles –A study by histology

Abstract

Back ground:Antihypertensive drug metosartan is well known for its action against hypertension in humans but recent research findings has shown that metosartan also induces endometrial carcinoma mainly leading to germ cell tumors. The individual components of metosartan namely telmisartan and Metoprolol are individually known for its proangiogenic properties in coronary tissue of animals and humans.

Method: male wistar rats of 3 months are grouped accordingly and dissected under hygiene condition and testes were dissected and fat tissue were removed and washed with distilled water and slides were prepared and  stained with eosin Y and air dried for scanning electron microscope.

Results: In this study the drug induce angiogenesis in testicles of men and suppose to cause tumor growth and metastasis. RNase A is well known for its anticarcinogenic activity and in this report it inhibited angiogenesis up to some extent when given in combinational treatment with metosartan and induces apoptosis of testis tissue when treated with RNase A alone.

Conclusion: Metosartan induces tumors in testicles of male rats by inhibiting the RNaseA