Impact of Fibrosis Related to TGF-B1and TNFR-1 Growth Factors in Renal Failure Patients

Abstract

Renal fibrosis (RF) is the sign of last common pathway of Chronic renal Disease, which is independent of the underlying etiology. Renal fibrosis is described by advanced tissue scarring such as glomerulosclerosis, tubulointerstitial fibrosis, and loss renal parenchyma, including tubular atrophy, loss podocyte and capillary. The current study was performed to identify the effect of TGF-B1and TNFR-1 growth factors in Renal Failure (RF) patients focusing on it is role on the renal fibrosis . This study comprises 68 patients diagnosed with kidney failure clinically and serologically (38 males and 30 females) and their age varies from (17 to 80) years

,also 20 healthy individuals as a healthy control group. SerumTGF-B1and TNFR-1 concentrations were measured using a commercially available ELISA kit. The results showed TGF-B1and TNFR-1 have significantly increased (232.3±14.46 , 2267± 104.78µg/ml) respectively when compared with the control (68.9± 11.58 and 299± 11.48pg/ml) respectively (p<0.05) .On other hand, the result showed TGF-B1and TNFR-1 level not influenced by the age of patients (p >0.05). However, TGF-B1and TNFR-1growth factors elevated gradually with advance the severity of the RF disease and the highest value showed in end stage of renal failure disease.