DNA Mutation Induced Toxicity

Abstract

Mutation are hereditary  changes   in genetic   information, resulting  from spontaneous  or xenobiotic induced  DNA damage. The number of proto-oncogenes  that must be activated  to convert a normal cell  into a malignant  cell is unknown  at present.   Point mutation and frame shift mutations were examined. Phosphorylation  is the most important in the synthesis of  purine and pyrimidine nucleosides and DNA damage. Impact of toxic effects  to phosphorylation reactions modifications and xenobiotic inducing was studied. In this paper a normal cell  into a malignant cell transformation  was considered