The Potential Role Of STK11 as a Biomarker for Intestinal Cancer

Zena Abdul-Ameer Mahdi (1) , Farqad A. Albaidhani (2) , Noor Abdulameer Oudah (3)
(1) Department of Medical Physics, college of Applied Medical Sciences, University of Kerbala, Karbala, Iraq. , Iraq
(2) Department of Engineering, College of Engineering Prosthetics and Orthotics, University of Kerbala Karbala, Iraq. , Iraq
(3) Department of Medical Physics, College of Applied of Medical Sciences, University of Kerbala, Karbala, Iraq. , Iraq

Abstract

Colorectal and small intestinal cancers together still pose a serious threat to world health. The necessity for trustworthy biomarkers is highlighted by the fact that early diagnosis is critical to better patient outcomes. In this regard, the serine/threonine kinase 11 (STK11) has come to light as a possible option. The STK11 gene codes for the serine/threonine kinase liver kinase B1 (LKB1), which is essential for preserving cellular polarity, adhesion, and metabolism. LKB1 inactivation is a frequent occurrence in many tumors, especially those that affect the gastrointestinal tract. The biological roles of STK11/LKB1 and its numerous contributions to the onset and spread of gastrointestinal cancer are reviewed in this study. This review addresses the role that STK11/LKB1 plays in the AMP-activated protein kinase (AMPK) pathway, which is a master regulator of cellular energy balance. Also, review how LKB1 regulates important signaling pathways, such as Wnt/?-catenin, PI3K/AKT/mTOR network, and how LKB1 depletion causes these pathways to become dysregulated, which in turn promotes cancer. It investigates the relationship between some gastrointestinal malignancies, such as Peutz-Jeghers syndrome, gastric cancer, and colorectal cancer, and LKB1 mutations. Lastly, we discuss the possible therapeutic implication of LKB1 signaling targeting in the management of gastrointestinal cancer.

Authors

Zena Abdul-Ameer Mahdi
Farqad A. Albaidhani
Noor Abdulameer Oudah
Mahdi, Z. A.-A., Albaidhani, F. A., & Oudah, N. A. (2024). The Potential Role Of STK11 as a Biomarker for Intestinal Cancer. Jour Med Resh and Health Sci, 7(8), 3188–3196. https://doi.org/10.52845/JMRHS/2024-7-8-2
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