Dyslipidemia and Diabetic Retinopathy in Moroccans Type 2 Diabetics Patients: A Cross-Sectional Study

Abstract

Introduction: Diabetic retinopathy (DR) is a leading cause of blindness among adults under 60 years’ old. The purpose of this study was to assess the factors associated with diabetic retinopathy in Type 2 diabetic subjects.

Methods: In a cross-sectional study, we enrolled type 2 diabetic patients from the endocrinology and diabetology department of the military hospital of Rabat assigned in two groups according to the presence or absence of DR. DR was diagnosed by fundus oculi. Fasting total cholesterol, triglyceride, HDL cholesterol, non-HDL cholesterol, and LDL cholesterol were assessed. A multiple logistic regression analysis was performed to identify independent factors associated with diabetic retinopathy.

Results: Two hundred and forty type 2 diabetic patients were enrolled. Age (p = 0.008), diabetes duration (p < 0.001), hypertension (p < 0.001), Microalbuminuria (p < 0.001), Dyslipidemia (p = 0.008), a non-HDL cholesterol > 1,3 g/l (p = 0.008) and serum triglycerides (p = 0.032) were significantly associated with DR. After adjusting for age, hypertension, diabetes duration and Microalbuminuria, total cholesterol (OR: 2.27; 95%IC: 1.02 – 5.07; p = 0.045), LDL cholesterol > 1 g/l (OR: 2.17; 95%IC: 1.09 – 4.34; p = 0,028) and non-HDL cholesterol > 1,3 g/l (OR: 2.46; 95%IC: 1.22 – 4.95; p = 0.012) were independent factors associated with DR.

Conclusion: Our data suggest that DR is independently associated with Serum lipids.

Introduction: Diabetic retinopathy (DR) is a leading cause of blindness among adults under 60 years’ old. The purpose of this study was to assess the factors associated with diabetic retinopathy in Type 2 diabetic subjects.

Methods: In a cross-sectional study, we enrolled type 2 diabetic patients from the endocrinology and diabetology department of the military hospital of Rabat assigned in two groups according to the presence or absence of DR. DR was diagnosed by fundus oculi. Fasting total cholesterol, triglyceride, HDL cholesterol, non-HDL cholesterol, and LDL cholesterol were assessed. A multiple logistic regression analysis was performed to identify independent factors associated with diabetic retinopathy.

Results: Two hundred and forty type 2 diabetic patients were enrolled. Age (p = 0.008), diabetes duration (p < 0.001), hypertension (p < 0.001), Microalbuminuria (p < 0.001), Dyslipidemia (p = 0.008), a non-HDL cholesterol > 1,3 g/l (p = 0.008) and serum triglycerides (p = 0.032) were significantly associated with DR. After adjusting for age, hypertension, diabetes duration and Microalbuminuria, total cholesterol (OR: 2.27; 95%IC: 1.02 – 5.07; p = 0.045), LDL cholesterol > 1 g/l (OR: 2.17; 95%IC: 1.09 – 4.34; p = 0,028) and non-HDL cholesterol > 1,3 g/l (OR: 2.46; 95%IC: 1.22 – 4.95; p = 0.012) were independent factors associated with DR.

Conclusion: Our data suggest that DR is independently associated with Serum lipids.