Evaluation of Twenty Chemical Elements in Thyroid with Hashimoto’s thyroiditis using X-Ray Fluorescent and Neutron Activation Analysis

  • Vladimir Zaichick

Abstract

Background: Hashimoto’s thyroiditis (HT) is an internationally important health problem.

Objectives: Role of chemical elements (ChE) in etiology and pathogenesis of HT is unclear. The aim of this exploratory study was to assess whether there were significant changes in thyroid tissue levels of twenty ChE (Ag, Br, Ca, Cl, Co, Cr, Cu, Fe, Hg, I, K, Mg, Mn, Na, Rb, Sb, Sc, Se, Sr, and Zn) are present in the HT transformed thyroid.

Methods

Twenty ChE of thyroid tissue were determined in 8 patients with HT. The control group included thyroid tissue samples from 105 healthy individuals. Measurements were conducted using combination of non-destructive methods such as energy dispersive X-ray fluorescent analysis and instrumental neutron activation analysis.

Results

Reduced mean values of Ca and I content almost in two times, while elevated level of Ag, Cu, Hg, and Na in 21, 1.2, 30, and 1.5 times, respectively, were found in thyroid with HT in comparison with normal level.

Conclusions

There are considerable changes in some ChE contents in tissue of thyroid with HT. Thus, it is reasonable to assume that the levels of these ChE in affected thyroid tissue can be used as HT markers. However, this topic needs additional studies.

How to Cite

Zaichick, V. . . (2021). Evaluation of Twenty Chemical Elements in Thyroid with Hashimoto’s thyroiditis using X-Ray Fluorescent and Neutron Activation Analysis. Journal of Medical Research and Health Sciences, 4(10), 1500–1510. https://doi.org/10.52845/JMRHS/2021-4-10-4

HTML
89

Total
72 0 0 0 5

Share

Search Panel

Vladimir Zaichick
Google Scholar
Pubmed
BMJ Journal


Most read articles by the same author(s)

Cited by

AllSince 2017
Citations749714
h-index1111
i10-index1212
0
260
130
65
195
2014201520162017201820192020202120224712223769148179251