Evaluation of Vitamin D Levels in Kidney Failure Hemodialysis Patients

Abstract

Introduction : Vitamin D is a fat-soluble prohormone whose metabolism is disrupted by chronic kidney disease (CKD). Indeed, it is in stage 3 of chronic kidney disease that an inadequate conversion of 25(OH)D to 1.25(OH)2D appears. The objective of the study was to evaluate the concentration of vitamin D and its correlation with parameters such as calcium and parathyroid hormone in a population with CKD and hemodialysis.

Methodology : This is a Study involving 35 hemodialysis patients. In these patients, epidemiological parameters were taken and blood samples were taken. Parameters such as vitamin D, calcium and parathyroid hormone were measured on each sample.

Results and Discussion : The majority of patients, 72%, had suboptimal vitamin D concentration, respectively 46% at the insufficiency stage (20-29 ng/ml) and 26% at the deficiency stage

(0-19 ng/ml) of which 3% were severe deficient ; with an average age of 48.97±14.95 years and a predominance of men (57%). A positive and negative correlation between vitamin D and serum calcium and vitamin D and parathyroid hormone, respectively; was found.

And also factors, such as age and gender have been identified as associated with decreased vitamin D concentration.